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Understanding tPEMFTM therapy

Understanding tPEMFTM therapy

Targeted Pulsed Electromagnetic Field (tPEMF) therapy delivers electromagnetic waves precisely tuned to stimulate an animal’s natural anti-inflammatory recovery process.

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Our clinical solutions are backed by research and evidence-based data

Using double-blind, peer-reviewed veterinary clinical studies, we’ve firmly rooted our products in the scientific veterinary community by verifying that our proprietary tPEMF technology is effective. PEMF technology has also been FDA cleared for human use since 2010.

Significant improvement in wound healing1

compared to placebo group

50%

reduction in opioid administration1

compared to placebo group

No side effects1

among the Loop-treated group

Reduced incisional pain2

compared to placebo group

Lower levels of GFAP indicating neuroprotective qualities2

compared to placebo group

Statistically greater degree of recovery of proprioception2

compared to placebo group

100%

of cases saw improvement in canine separation anxiety symptoms3

among the Calmer Canine-treated group

50%

of pet parents saw improvement in their dog’s anxiety after 1-week of treatments4

compared to placebo group

50%

of pet parents reported full resolution of symptoms after 6-weeks of treatment3

compared to placebo group

67%

of dogs maintained their improvement 2-weeks after treatment was discontinued

among the Calmer Canine-treated group

Watch the before and after footage from the Calmer Canine pilot study

1 Leilani X. Alvarez, John McCue, Nathaniel K. Lam, Gulce Askin, and Philip R. Fox (2019) Effect of Targeted Pulsed Electromagnetic Field Therapy on Canine Postoperative Hemilaminectomy: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Journal of the American Animal Hospital Association: March/April 2019, Vol. 55, No.

2Zidan N, Fenn J, Griffith E, Early PJ, Mariani CL, Muñana KR, Guevar J, Olby NJ. J Neurotrauma
. 2018 Aug 1;35(15):1726-1736. doi: 10.1089/neu.2017.5485. Epub 2018 Apr 2.

3 Margaret E. Gruen, Emily Griffith, Judy Korman. Treatment of Canine Separation Anxiety Using a Pulsed Electromagnetic Field Device: A Pilot Study. Presented July 2019 at the IVBM Conference, Washington DC.

4Pankratz K, Korman J, Emke C, Johnson B, Griffith EH, Gruen ME. Randomized, Placebo-Controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety. Front Vet Sci. 2021 Dec 20;8:775092. doi: 10.3389/fvets.2021.775092. PMID: 34988140; PMCID: PMC8720769.

The history of tPEMF technology

1831
Michael Faraday, a British chemist and physicist, discovers electromagnetic induction.
1831
Michael Faraday, a British chemist and physicist, discovers electromagnetic induction.5
1898
Tesla publishes “The Electrical Engineer” and discusses invention of magnetic loop coil, still used today; led to magnetic strength being measured in Teslas (T).6
1950’s
Scientists begin serious research into PEMF therapy as a healing agent.7
1970
Arthur A. Pilla, PhD develops a relatively low-powered PEMF device – a bone growth stimulator (BGS) – to heal recalcitrant factures.8
1979
  • FDA provides premarket approval for a PEMF device for the healing of nonunion fractures.9
  • The Assisi LOOP’s patented signal targeting the upregulation of nitric oxide is developed by Dr. Arthur Pilla and clinically supported for treating non-healing fractures.10
1998
  • Additional clinical research is published on use of PEMF for treating urinary incontinence and muscle stimulation.11
  • The Nobel Prize for Medicine and Physiology is awarded to three American pharmacologists for their work on nitric oxide as a signaling molecule in the cardiovascular system.12
2004

Clinical research is published supporting the efficacy of PEMF therapy for cervical fusion patients at high-risk of non-fusion.13

2006

Clinical research is published supporting use of PEMF therapy for treatment of depression and anxiety.14

2008
The company Assisi Animal Health is born, incorporating Dr. Pilla’s technology into their portfolio of animal health products.
2008

The Assisi Loop is developed based upon clinical research for PEMF signal that reduces pain and edema.15

2011

A scientific review of research is published on the use of PEMF therapy in oncology.16

2013
Assisi Animal Health begins validating Assisi Loop tPEMF technology through clinical research studies, now compiled above.
2019

The Calmer Canine Anxiety Treatment System is unveiled, utilizing a unique tPEMF signal to reduce inflammation in the anxiety center of the brain.

2019
A Calmer Canine pilot study presented at the IVBM Conference in Washington, DC found significant improvement in anxiety, with half of owners reporting complete resolution of separation anxiety symptoms after six weeks of therapy.17
2021
A double-blind, randomized, placebo-controlled study found that Calmer Canine significantly reduces signs of separation anxiety.18

5Al-Khalili, J. The birth of the electric machines: a commentary on Faraday (1832) ‘Experimental researches in electricity’. Philos Trans A Math Phys Eng Scie.,20015 April 13; 373(2039):20140208.

6Nikola Tesla. http://web.mit.edu/most/Public/Tesla1/etradict.htm. Last accessed 11/10/20.

7Strauch, B., et al. Mar 2009. Evidence-Based use of Pulsed Electromagnetic Field Therapy in Clinical Plastic Surgery. Aesthetic Surgery J, v29(2); 135-143

8Oct 2015. Pilla, A.https://www.bems.org/node/15190#:~:text=Dr.-,Arthur%20A.,He%20was%2080%20years%20old. Last accessed 11/10/20.

9Reclassification of Non-Invasive Bone Growth Stimulators, FDA Executive Summary.

10Gaynor, et al. 2018. Veterinary applications of pulsed electromagnetic field therapy, Res. Vet.Sci.,119; 1-8.

11Quek, P. 2005. A critical review on magnetic stimulation: What is its role in the management of pelvic floor disorders?. Curr Opin Urol. 15(4); 231-5.

12SoRelle, R. 1998. Nobel prize awarded to scientist for nitric oxide discoveries. J. Am. Heart Assoc., 98;2365-2366.

13Coric, et al. 2018. Pulsed electromagnetic field stimulation may improve fusion rates in cervical arthrodesis in high-risk populations. Bone Jt. Res., 7(2); 124-130.

14Transcranial Magnetic Stimulation (TMS). https://adaa.org/finding-help/transcranial-magnetic-stimulation. Last accessed 11/10/20.

15Strauch, et al. 2009. Evidence-Based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet. Surg. J., 29(2); 135-143.

16 Vadalà, et al. 2016. Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology. Cancer Med., 5(11); 3128-3139.

17 Margaret E. Druen, Emily Griffith, Judy Korean. Treatment of Canine Separation Anxiety Using  a Pulsed Electromagnetic Field Device: A Pilot Study. Presented July 2019 at the IVBM Conference, Washington DC.

18 Katerine Pankratz, et al. 2021. Randomized, Placebo-Controlled Prospective Clinical Trial Evaluating the Efficacy of the Assisi Anti-anxiety Device (Calmer Canine) for the Treatment of Canine Separation Anxiety.  Frontiers in Veterinary Science Vol 8, December 20

 

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